complement system — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38332	Complement factor D-IN-2		Complement System
	Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.		Complement System
TP1304	Compstatin		Complement System
	Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.		Complement System
T9915	Eculizumab		Complement System
	Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5		Complement System
T8509	Danicopan	ACH-4471	Complement System
	Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ...		Complement System
T9189	Iptacopan hydrochloride	Iptacopan HCl,LNP023 hydrochloride	Complement System
	Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity b...		Complement System
T12851	SB290157 trifluoroacetate		Complement System
	SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).		Complement System
T3638	Leukadherin-1		Integrin , Complement System
	Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.		Integrin , Complement System
T9316	JR14a	5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride	Complement System
	JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.		Complement System
T17250	W-54011		ROS , Complement System
	W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g...		ROS , Complement System
T7776	ADH-503	GB1275	Complement System
	ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.		Complement System
T0945	Cyclosporin A	Cyclosporine A,Ciclosporin,Cyclosporine	Phosphatase , Antibiotic , Complement System
	Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM).		Phosphatase , Antibiotic , Complement System
T1076	Dexamethasone	MK 125,Prednisolone F,NSC 34521,Hexadecadrol	Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T7497	C3a (70-77)	Complement 3a (70-77),C3a 70-77	Complement System
	C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.		Complement System
T13379	(Z)-Leukadherin-1	ADH-503 free base	Complement System
	(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.		Complement System
T40646	Lipoteichoic acid		Complement System
	Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway.		Complement System
T38287	C3a Receptor Agonist	C3a receptor agonist 1,Complement 3a Receptor Agonist	Complement System
	C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin...		Complement System
T38951	Isatuximab	SAR-650984,hu38SB19,Isatuximab-irfc	Apoptosis , CD38
	Isatuximab is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38 in malignant cells of the hematological system and is a highly expressed protein in multiple myeloma. Isatuximab has ...		Apoptosis , CD38
TN3430	Apigenin 4'-O-rhamnoside		Others
	Apigenin-4'-O-rhamnosylglucoside can strongly inhibit the classical pathway of the complement system.		Others
T11269	FD-IN-1		Others
	FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a...		Others
T75775	Compstatin TFA
	Compstatin TFA, a potent inhibitor of the complement system C3 characterized by species specificity, is a 13-residue cyclic peptide. It selectively binds to baboon C3 and demonstrates resistance to proteolytic cleavage i...